Luís Aragón

This study shows that the FACT complex regulates cohesin dynamics on chromatin, facilitating loop extrusion and preventing cohesin accumulation in transcribed regions.

This study identifies a bipartite mechanism for condensin II activation in mitosis, showing how M18BP1 relieves autoinhibition and enables DNA loop formation.

The paper identifies a conserved mechanism by which KIF4A activates condensin I through direct binding to NCAPG and displacement of auto-inhibitory interactions.

This study shows that dimeric SMC motors switch extrusion directionality based on DNA tension, with cohesin being constitutively biased toward one-sided extrusion.

The paper shows condensin creates a short negatively supercoiled DNA loop during ATP usage, which may merge with an extruding loop.

This study shows that FACT is required for cohesin stability on chromatin and the formation of cohesin-dependent TAD-like structures, but not sister chromatid cohesion.

This study shows that PP4 phosphatase dephosphorylates Rad53, enhancing DNA end resection and recombinational repair by counteracting Rad9's inhibitory effect on Sgs1/Dna2.