The ontogeny of myeloid-stromal synovial tissue niches in rheumatoid arthritis.
Aziza Elmesmari, Domenico Somma, Lucy MacDonald, Jack Frew, Zuzanna Kuczynska, Clara Di Mario, Lavinia Agra Coletto, Shravani Baruah, Denise Campobasso, Theodoros Simakou, Eva M.L. Philippon, Sander W. Tas, Marcus Doohan, Roberta Benvenuto, Dario Bruno, , Mariola Kurowska‐Stolarska
This study shows human synovial tissue-resident macrophages develop from monocytes guided by fibroblast-derived cues in specific spatial niches, using a novel organoid system.
bioRxiv · Oct 29, 2025 · PreprintImmunology