Dysregulated Microglial Synaptic Engulfment in Diffuse Midline Glioma
Rebecca A. Mancusi, Eva U. Tatlock, Kiarash Shamardani, Lehi Acosta-Alvarez, Richard Drexler, Vrunda S. Trivedi, Avishai Gavish, Kouta Niizuma, Neeraj Soni, Pamelyn J. Woo, Sara B. Mulinyawe, Samin Maleki Jahan, Natalie A. Logan, Karen E. Malacon, Youkyeong Gloria Byun, , Michelle Monje
This study investigates how microglial synaptic engulfment is dysregulated in diffuse midline glioma, leading to imbalanced excitatory-inhibitory synapse ratios and increased neuronal hyperexcitability.
bioRxiv · Dec 25, 2025 · PreprintNeuroscience