Lehi Acosta-Alvarez

Host genotype and sex shape influenza evolution and defective viral genomes

The paper shows host genotype and sex influence influenza virus evolution and defective genome formation through experimental adaptation and structural analysis.

Dysregulated Microglial Synaptic Engulfment in Diffuse Midline Glioma

This study investigates how microglial synaptic engulfment is dysregulated in diffuse midline glioma, leading to imbalanced excitatory-inhibitory synapse ratios and increased neuronal hyperexcitability.

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice

This study shows that CAR T cell therapy in mice causes cognitive impairment through CNS immune dysregulation, microglial reactivity, and disrupted oligodendroglial homeostasis.

Progenitor cell integration into a barrier epithelium during adult organ turnover

The paper investigates how stem cell progeny in Drosophila intestinal epithelium acquire barrier-forming structures through a transient niche, enabling their integration into the epithelial barrier.

Mild respiratory SARS-CoV-2 infection can cause multi-lineage cellular dysregulation and myelin loss in the brain

Respiratory-restricted SARS-CoV-2 infection in mice, without brain virus, drives white matter microglial reactivity, impaired neurogenesis, oligodendrocyte depletion and myelin loss lasting at least 7 weeks.