Temporal epigenome modulation enables efficient bacteriophage engineering and functional analysis of phage DNA modifications
N. Pozhydaieva, F. A. Billau, M. Wolfram-Schauerte, A. A. R. Rojas, N. Paczia, D. Schindler, K. Höfer
The paper describes a method to temporarily modulate phage DNA modifications using NgTET, enabling efficient Cas-mediated mutagenesis and functional analysis of phage epigenome.
bioRxiv · Jan 28, 2024Microbiology