T. Glatter

Promiscuous NAD-dependent dehydrogenases enable efficient bacterial growth on the PET monomer ethylene glycol

This study identifies NAD-dependent dehydrogenases in Paracoccus denitrificans that enable efficient bacterial growth on ethylene glycol, with implications for biotechnological applications.

Yersinia actively downregulates type III secretion and adhesion at higher cell densities

This study shows Yersinia enterocolitica suppresses T3SS expression and adhesion at high cell densities through VirF downregulation and CsrBC-mediated mechanisms.

The SPFH complex HflK-HflC regulates aerobic respiration in bacteria

This study identifies the HflK-HflC complex as essential for aerobic respiration in E. coli by regulating IspG abundance and ubiquinone levels.

Enhanced metabolic entanglement emerges during the evolution of an interkingdom microbial community

This study evolves an engineered microbial community to show how metabolic interactions increase, leading to interdependence and indirect selection for mutualism.

Multiple levels of transcriptional regulation control glycolate metabolism in Paracoccus denitrificans

This study identifies multiple transcriptional regulators controlling glycolate metabolism in Paracoccus denitrificans, revealing a complex regulatory network for carbon assimilation.

A deterministic, c-di-GMP-dependent genetic program ensures the generation of phenotypically similar, symmetric daughter cells during cytokinesis

Identification, structure and function of the methyltransferase involved in the biosynthesis of the dithiolopyrrolone antibiotic xenorhabdin

This study identifies and characterizes XrdM, an amide methyltransferase involved in dithiolopyrrolone antibiotic biosynthesis, and shows it is distinct from DtpM in structure and function.

A conserved cell-pole determinant organizes proper polar flagellum formation

This study identifies FipA as a novel protein required for FlhF-mediated polar flagellum synthesis in multiple gamma-proteobacteria, independent of HubP.

Purine nucleotide limitation undermines antibiotic action in clinical Escherichia coli

This study identifies purine nucleotide limitation as a mechanism conferring antibiotic resistance in E. coli by reducing ATP supply and upregulating the purine nucleoside transporter PunC.

During heat stress in Myxococcus xanthus, the CdbS PilZ domain protein, along with two PilZ-DnaK chaperones, perturbs chromosome organization and accelerates cell death

The paper shows that in Myxococcus xanthus, CdbA regulates CdbS levels to maintain chromosome organization, and its depletion leads to CdbS over-accumulation, causing cell death, especially under heat stress.

Repertoire and abundance of secreted virulence factors shape the pathogenic capacity of Pseudomonas syringae pv. aptata

This study identifies strain-specific secretome features in Pseudomonas syringae pv. aptata that correlate with pathogenicity.

DipM controls multiple autolysins and mediates two regulatory feedback loops promoting cell constriction in C. crescentus

This paper identifies DipM as a LytM factor that regulates autolysins through two feedback loops to promote cell constriction in C. crescentus.

Structural and functional analysis of the cerato-platanin-like effector protein Cpl1 suggests diverging functions in smut fungi

The paper presents the atomic structures of Cpl1 and Uvi2 from smut fungi, revealing their chitin-binding properties and suggesting diverging functions through structural differences.

Constitutive production of flagellar proteins is required for proper flagellation in Shewanella putrefaciens

The paper shows that constitutive expression of flagellar proteins is necessary for proper flagellation in Shewanella putrefaciens, revealing a 'tier zero' of basal expression required for flagellar synthesis.

Evidence for a widespread third system for bacterial polysaccharide export across the outer membrane comprising a composite OPX/β-barrel translocon

The paper identifies a novel composite translocon for polysaccharide export in Gram-negative bacteria, composed of EpsX and EpsY, and shows its widespread presence across species.

Pilotins are mobile T3SS components involved in assembly and substrate specificity of the bacterial type III secretion system

The paper investigates the role of pilotins in T3SS assembly and substrate specificity, finding they are mobile and affect early substrate export but not late substrates.

A GGDEF domain serves as a spatial on-switch for a phosphodiesterase by direct interaction with a polar landmark protein

The paper shows how the GGDEF domain of PdeB acts as a spatial on-switch by interacting with HubP to restrict phosphodiesterase activity to the flagellated cell pole, influencing surface interaction and environmental spreading.

A repurposed, non-canonical cytochrome c, chaperones calcium binding by PilY1 for type IVa pili formation

The paper identifies a non-canonical cytochrome c, TfcP, that binds calcium to stabilize PilY1.1, enabling T4aP function across a broader range of calcium concentrations.

A viral ADP-ribosyltransferase attaches RNA chains to host proteins

This study identifies a viral ADP-ribosyltransferase, ModB, that attaches RNA chains to host proteins through an 'RNAylation' reaction, revealing a novel role for NAD-RNA in modulating host translation.

Vibrio cholerae biofilm dispersal regulator causes cell release from matrix through type IV pilus retraction

This study identifies VbdR as a regulator of Vibrio cholerae biofilm dispersal, showing it induces type IV pilus retraction and matrix protease expression to release cells from the biofilm matrix.

Small RNA directs symbiosis, virulence, and natural products biosynthesis in entomopathogenic bacteria

This study identifies ArcZ, an Hfq-dependent sRNA, as essential for small molecule production in entomopathogenic bacteria, revealing its broad regulatory role beyond secondary metabolites.

Structural and proteomic changes in viable but non-culturable Vibrio cholerae

This study investigates structural and proteomic changes in Vibrio cholerae during the viable but non-culturable state using electron cryo-tomography and proteomic analysis.