Author

N. Paczia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 3 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 4 Research Focus:metabolism & bioenergetics· 4 Assay:bulk RNA-seq· 3 Assay:metabolomics· 3 Organism:bacteria (other)· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2

Frequent Co-Authors

G. Angelidou· 3 shared A. A. R. Rojas· 2 shared C. L. Linster· 2 shared D. Schindler· 2 shared K. Höfer· 2 shared M. Wolfram-Schauerte· 2 shared N. Pozhydaieva· 2 shared T. Glatter· 2 shared

Activity by Year

2018-2024 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersEvolutionary Biology

G. Angelidou

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

T4 phage RNA is NAD-capped and alters the NAD-cap epitranscriptome of Escherichia coli during infection

M. Wolfram-Schauerte, H. Keuthen, A. Moskalchuk, T. Ueffing, N. Pozhydaieva, A. A. R. Rojas, D. Schindler, S. Kaiser, N. Paczia, K. Höfer

This study identifies NAD-capped RNAs during T4 phage infection of E. coli, showing dynamic changes in NAD-capping and revealing a phage-encoded Nudix hydrolase involved in NAD-RNA decapping.

bioRxiv · Apr 4, 2024 · PreprintMicrobiology

Enhanced metabolic entanglement emerges during the evolution of an interkingdom microbial community

G. Scarinci, J.-L. Ariens, G. Angelidou, S. Schmidt, T. Glatter, N. Paczia, V. Sourjik

This study evolves an engineered microbial community to show how metabolic interactions increase, leading to interdependence and indirect selection for mutualism.

bioRxiv · Mar 30, 2024Evolutionary Biology

Multiple levels of transcriptional regulation control glycolate metabolism in Paracoccus denitrificans

L. Schada von Borzyskowski, L. Hermann, K. Kremer, S. Barthel, B. Pommerenke, T. Glatter, N. Paczia, E. Bremer, T. J. Erb

This study identifies multiple transcriptional regulators controlling glycolate metabolism in Paracoccus denitrificans, revealing a complex regulatory network for carbon assimilation.

bioRxiv · Mar 11, 2024 · PreprintMicrobiology

Temporal epigenome modulation enables efficient bacteriophage engineering and functional analysis of phage DNA modifications

N. Pozhydaieva, F. A. Billau, M. Wolfram-Schauerte, A. A. R. Rojas, N. Paczia, D. Schindler, K. Höfer

The paper describes a method to temporarily modulate phage DNA modifications using NgTET, enabling efficient Cas-mediated mutagenesis and functional analysis of phage epigenome.

bioRxiv · Jan 28, 2024Microbiology

MprF-mediated immune evasion is necessary for Lactiplantibacillus plantarum resilience in Drosophila gut during inflammation

A. Arias-Rojas, A. Arifah, G. Angelidou, B. Alshaar, U. Schombel, E. Forest, D. Frahm, V. Brinkmann, N. Paczia, C. Beisel, N. Gisch, I. Iatsenko

This study shows that MprF in Lactiplantibacillus plantarum helps it survive in Drosophila gut during inflammation by reducing immune response and maintaining microbial stability.

bioRxiv · Jan 9, 2024 · PreprintMicrobiology

NAD+ metabolism is a key modulator of bacterial respiratory epithelial infections

B. Klabunde, A. Wesener, W. Bertrams, I. Beinborn, N. Paczia, K. Surmann, S. Blankenburg, J. Wilhelm, J. Serrania, K. Knoops, E. M. Elsayed, K. Laakmann, A. L. Jung, A. Kirschbaum, M. Abu Mraheil, , B. Schmeck

The paper investigates how NAD+ metabolism affects bacterial respiratory infections, finding that modulating NAD+ levels impacts both host and bacterial outcomes.

bioRxiv · Apr 13, 2023Immunology

Ketosynthase engineering enhances activity and shifts specificity towards non-native extender units in type I linear polyketide synthase

P. D. Gerlinger, G. Angelidou, N. Paczia, T. J. Erb

This study engineers the ketosynthase domain of a polyketide synthase to enhance activity and shift specificity towards non-native extender units in vitro.

bioRxiv · Feb 16, 2023 · PreprintBiochemistry

PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains Treg homeostasis

E. Danileviciute, N. Zeng, C. Capelle, N. Paczia, M. A. Gillespie, H. Kurniawan, D. Coowar, D. Vogt-Weisenhorn, G. Gomez-Giro, M. Grusdat, A. Baron, C. Guerin, D. G. Franchina, C. Leonard, O. Domingues, , F. Q. He

This study shows PARK7/DJ-1 enhances PDH activity in Tregs by inhibiting PDHA phosphorylation, maintaining Treg homeostasis and reducing EAE severity.

bioRxiv · Dec 20, 2019Biochemistry

NAD(P)HX repair deficiency causes central metabolic perturbations in yeast and human cells

J. Becker-Kettern, N. Paczia, J.-F. Conrotte, C. Zhu, O. Fiehn, P. P. Jung, L. M. Steinmetz, C. L. Linster

This study shows that NAD(P)HX repair deficiency in yeast and human cells causes metabolic perturbations, including NADHX accumulation, NAD+ depletion, and impaired mitochondrial function.

bioRxiv · Jul 5, 2018Biochemistry