M. G. Manz

Circulating senescent myeloid cells drive blood brain barrier breakdown and neurodegeneration

This study identifies circulating senescent myeloid cells as drivers of blood-brain barrier breakdown and neurodegeneration in LCH-ND.

Anti-CD117 CAR T cells incorporating a safety switch eradicate human acute myeloid leukemia and hematopoietic stem cells

This study develops anti-CD117 CAR T cells with a safety switch to target and eliminate acute myeloid leukemia and hematopoietic stem cells in preclinical models.

SAMHD1 mutations in mantle cell lymphoma are recurrent and confer in vitro resistance to nucleoside analogues

CD8 T cells induce destruction of bone marrow stromal niches and hematopoietic stem cell dysfunction in chronic viral infections

This study shows chronic viral infections impair bone marrow stromal networks and HSC function via CD8 T cell-mediated inflammation.

Global transcriptomic profiling of the bone marrow stromal microenvironment during postnatal development, aging and inflammation

This study profiles the transcriptome of bone marrow stromal subsets across development, aging, and inflammation in mice, revealing dynamic transcriptional changes and their link to hematopoietic function.

A Highly Efficient and Faithful MDS Patient-Derived Xenotransplantation Model for Pre-Clinical Studies

This paper develops a novel MDS patient-derived xenotransplantation model in MISTRG mice that faithfully represents all MDS subtypes and enables effective drug testing.