G. Tonon

KDM6A Regulates Immune Response Genes in Multiple Myeloma

This study shows KDM6A regulates immune response genes in multiple myeloma by activating NLRC5 and CIITA, and its loss reduces MHC expression, which can be reversed by HDAC3 inhibitors.

The Minimal Dataset for Cancer of the 1+Million Genomes Initiative

The paper develops a standardized data model for cancer genomics to enable interoperable data sharing across countries.

Evolutionary fingerprints of EMT in pancreatic cancers

This study investigates the role of EMT in pancreatic cancer evolution and metastasis, showing that mesenchymal lineages drive chromosomal instability and clonal evolution.

A novel method for characterising the inter- and intra-lake variability of CH4 emissions: validation and application across a latitudinal transect in the Alpine region

The paper develops and validates a mobile eddy covariance platform to measure CH4 emissions from Alpine lakes, showing that fluxes can be predicted by environmental parameters and revealing high variability in shallow lakes.

Rapid longitudinal SARS-CoV-2 intra-host emergence of novel haplotypes regardless of immune deficiencies

The paper analyzes SARS-CoV-2 genomic data from a quarantined Italian town, showing rapid intra-host emergence of novel viral haplotypes within two weeks, regardless of immune status or symptoms.