Author

F. F. Diehl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

C. A. Lewis· 2 shared M. G. Vander Heiden· 2 shared A. Conway· 1 shared A. L. Robichaud· 1 shared A. Puissant· 1 shared A. Su· 1 shared C. S. Nabel· 1 shared G. Alexe· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersCell Biology

C. A. Lewis

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Author profile →

2 papers

Recent·Most cited

Nucleotide imbalance decouples cell growth from cell proliferation

F. F. Diehl, T. P. Miettinen, R. Elbashir, C. S. Nabel, S. R. Manalis, C. A. Lewis, M. G. Vander Heiden

The paper shows that nucleotide imbalances during S phase disrupt DNA replication and cell proliferation, requiring replication stress signaling for survival.

bioRxiv · Dec 6, 2021Cell Biology

Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy.

Y. Pikman, N. Ocasio-Martinez, G. Alexe, S. Kitara, F. F. Diehl, A. L. Robichaud, A. Conway, A. Su, J. Qi, G. Roti, C. A. Lewis, A. Puissant, M. G. Vander Heiden, K. Stegmaier

This study identifies SHMT1 and SHMT2 as therapeutic targets in T-ALL by showing their inhibition impairs leukemia progression and is effective despite methotrexate resistance.

bioRxiv · Feb 6, 2020Cancer Biology