Author

Y. Pikman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

K. Stegmaier· 2 shared M. G. Vander Heiden· 2 shared A. Conway· 1 shared A. K. Shalek· 1 shared A. L. Robichaud· 1 shared A. M. Darnell· 1 shared A. Puissant· 1 shared A. Su· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersCancer Biology

K. Stegmaier

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Author profile →

3 papers

Recent·Most cited

Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress

B. T. Do, P. P. Hsu, S. Y. Vermeulen, Z. Wang, T. Hirz, K. L. Abbott, N. Aziz, J. M. Replogle, S. Bjelosevic, J. Paolino, S. Nelson, S. Block, A. M. Darnell, R. Ferreira, H. Zhang, , M. G. Vander Heiden

The paper shows that nucleotide depletion and DNA replication stress drive cell fate transitions in hematopoietic systems by activating lineage-specific maturation genes.

bioRxiv · Aug 16, 2022Cancer Biology

Single-cell analysis reveals mechanisms of plasticity of leukemia initiating cells

V. Morris, W. Marion, T. Hughes, P. Sousa, P. Sensharma, Y. Pikman, M. Harris, A. K. Shalek, T. North, G. Q. Daley, E. Lummertz da Rocha, G. Rowe

The paper uses single-cell transcriptomics to show that leukemia initiating cells can convert between states, with MYC-driven oxidative phosphorylation controlling this plasticity.

bioRxiv · Apr 29, 2020 · PreprintCancer Biology

Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy.

Y. Pikman, N. Ocasio-Martinez, G. Alexe, S. Kitara, F. F. Diehl, A. L. Robichaud, A. Conway, A. Su, J. Qi, G. Roti, C. A. Lewis, A. Puissant, M. G. Vander Heiden, K. Stegmaier

This study identifies SHMT1 and SHMT2 as therapeutic targets in T-ALL by showing their inhibition impairs leukemia progression and is effective despite methotrexate resistance.

bioRxiv · Feb 6, 2020Cancer Biology