C. A. Lewis

Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability

This study profiles metabolites in renal cell carcinoma tissue and fluid to show that nutrient availability is more influenced by tissue-specific factors than tumor-driven changes.

Screening in serum-derived medium reveals differential response to compounds targeting metabolism

The paper screens compounds targeting metabolism in serum-derived medium to identify differential responses in cancer cells, aiming to improve drug response prediction.

Viral Airway Injury Promotes Cell Engraftment in an In Vitro Model of Cystic Fibrosis Cell Therapy

This study shows that viral airway injury enhances cell engraftment in an in vitro CF model by creating conditions that favor non-CF cell integration and functional CFTR recovery.

Cancer tissue of origin constrains the growth and metabolism of metastases

This study shows that cancer tissue-of-origin influences the metabolism and growth preferences of both primary and metastatic tumors.

S-adenosylmethionine synthases specify distinct H3K4me3 populations and gene expression patterns during heat stress

The paper identifies distinct roles of SAMS-1 and SAMS-4 in regulating H3K4me3 and gene expression during heat stress in C. elegans.

Nucleotide imbalance decouples cell growth from cell proliferation

The paper shows that nucleotide imbalances during S phase disrupt DNA replication and cell proliferation, requiring replication stress signaling for survival.

Robust W1282X-CFTR rescue by a small molecule GSPT1 degrader

The paper develops Bmi-1/hTERT cell lines to model CFTR variants and shows that CC-90009 partially rescues W1282X-CFTR function while affecting sodium channel activity.

The Burden Borne by Protein Methyltransferases: Rates and Equilibria of Nonenzymatic Methylation of Amino Acid Side-Chains by SAM in Water

The paper measures the rates and equilibria of nonenzymatic methylation of amino acid side-chains by SAM in water, revealing the thermodynamics and kinetics of methyl transfer reactions.

MCART1 is required for mitochondrial NAD transport

The paper identifies MCART1 as a mitochondrial NAD+ transporter in human cells by showing its essentiality with ETC components and its effect on NAD levels and mitochondrial function.

Cell Programmed Nutrient Partitioning in the Tumor Microenvironment

The paper measures nutrient uptake in the tumor microenvironment using PET tracers and finds cancer cells prefer glutamine while myeloid cells consume most glucose.

Dihydroxyacetone phosphate signals glucose availability to mTORC1

This study identifies dihydroxyacetone phosphate (DHAP) as the glucose-derived metabolite that activates mTORC1, linking glucose availability to cell growth regulation.

Methionine synthase is essential for cancer cell proliferation in physiological folate environments

This study shows methionine synthase is essential for cancer cell proliferation under physiological folate conditions but not in standard cell culture.

Increased demand for NAD+ relative to ATP drives aerobic glycolysis

The paper shows that increased NAD+ demand relative to ATP demand drives aerobic glycolysis by impairing NAD+ regeneration and promoting fermentation.

Isoproterenol-induced Cardiac Dysfunction in Male and Female C57Bl/6 Mice

This study investigates sex differences in isoproterenol-induced cardiac dysfunction in C57Bl/6 mice, finding no significant sex-related differences in cardiac response to acute or chronic adrenergic stimulation.

Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1

This study shows that pancreatic cancer cells can adapt to nutrient deprivation by stabilizing glutamine synthetase via mTORC1, and this adaptation is reversible.

Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy.

This study identifies SHMT1 and SHMT2 as therapeutic targets in T-ALL by showing their inhibition impairs leukemia progression and is effective despite methotrexate resistance.

Quantification of microenvironmental metabolites in murine cancer models reveals determinants of tumor nutrient availability

The paper quantifies microenvironmental metabolites in murine cancer models and identifies factors affecting tumor nutrient availability.