Author

F. J. Barrat

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

C. YANG· 2 shared L. B. Ivashkiv· 2 shared M. D. Ah Kioon· 2 shared R. Yuan· 2 shared Y. Du· 2 shared B. Mishra· 1 shared C. Brauner· 1 shared G. Chesi· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersImmunology

C. YANG

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Author profile →

2 papers

Recent·Most cited

CXCL4 signaling and gene induction in human monocytes

C. YANG, R. Yuan, B. Mishra, R. D. Bill, Y. Zhang, Y. Du, M. D. Ah Kioon, F. J. Barrat, L. B. Ivashkiv

This study investigates CXCL4 signaling in human monocytes, identifying NF-κB and TBK1-JNK pathways and a potential role for TLR4, while noting challenges in isolating CXCL4's effects from endotoxin contamination.

bioRxiv · Oct 26, 2022 · PreprintImmunology

Costimulation of TLR8 responses by CXCL4 in Human Monocytes Mediated by TBK1-IRF5 Signaling and Epigenomic Remodeling

C. YANG, M. Bachu, Y. Du, C. Brauner, R. Yuan, M. D. Ah Kioon, G. Chesi, F. J. Barrat, L. B. Ivashkiv

This study shows CXCL4 enhances TLR8 responses in human monocytes by promoting inflammatory gene transcription and IL-1β production through TBK1-IRF5 signaling and chromatin remodeling.

bioRxiv · Mar 28, 2022 · PreprintImmunology