Author

M. Bachu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2

Frequent Co-Authors

K. Ozato· 2 shared A. B. Pernis· 1 shared A. C. Shetty· 1 shared A. Coulter· 1 shared A. Das· 1 shared A. Dey· 1 shared A. M. Rosenfeld· 1 shared B. L. Foster· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCell Biology

K. Ozato

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Author profile →

4 papers

Recent·Most cited

BRD4 directs mitotic cell division by inhibiting DNA damage

T. Wu, H. Hou, A. Dey, M. Bachu, X. Chen, J. Wisniewski, F. Kudoh, C. Chen, S. Chauhan, H. Xiao, R. Pan, K. Ozato

This study shows BRD4 is essential for normal cell growth by regulating cell cycle genes and preventing DNA damage during replication and mitosis.

bioRxiv · Jul 2, 2023 · PreprintCell Biology

Costimulation of TLR8 responses by CXCL4 in Human Monocytes Mediated by TBK1-IRF5 Signaling and Epigenomic Remodeling

C. YANG, M. Bachu, Y. Du, C. Brauner, R. Yuan, M. D. Ah Kioon, G. Chesi, F. J. Barrat, L. B. Ivashkiv

This study shows CXCL4 enhances TLR8 responses in human monocytes by promoting inflammatory gene transcription and IL-1β production through TBK1-IRF5 signaling and chromatin remodeling.

bioRxiv · Mar 28, 2022 · PreprintImmunology

Sex-specific differences in the function and differentiation of ABCsmark TLR7-driven immunopathogenesis

E. Ricker, M. Manni, D. Flores-Castro, D. Jenkins, S. Gupta, J. Rivera-Correa, W. Meng, A. M. Rosenfeld, T. Pannellini, M. Bachu, Y. Chinenov, P. K. Sculco, R. Jessberger, E. T. Luning Prak, A. B. Pernis

The paper shows sex-specific differences in ABCs expansion, ISG signature upregulation, and differentiation in TLR7-driven immunopathogenesis, with Tlr7 duplication in males exacerbating disease severity.

bioRxiv · Jan 20, 2021 · PreprintImmunology

Monocyte Subsets with High Osteoclastogenic Potential and Their Epigenetic Regulation Orchestrated by IRF8

A. Das, X. Wang, J. Kang, A. Coulter, A. C. Shetty, M. Bachu, S. Brooks, S. Dell'Orso, B. L. Foster, X. Fan, K. Ozato, M. Somerman, V. Thumbigere Math

The paper identifies monocyte subsets with high osteoclastogenic potential and shows IRF8 regulates their epigenetic and transcriptional programs.

bioRxiv · Jun 2, 2020Immunology