F. Melchior

The intrinsically disordered N-terminus of SUMO1 is an intramolecular inhibitor of SUMO1 interactions

The paper identifies the intrinsically disordered N-terminus of SUMO1 as an intramolecular inhibitor of SUMO-SIM interactions, revealing a mechanism of disorder-based autoinhibition.

Fasting-sensitive SUMO-switch on Prox1 controls hepatic cholesterol metabolism

This study shows that SUMOylation of Prox1 regulates hepatic cholesterol metabolism in response to fasting, with implications for metabolic health.

SCFFbxw5 targets MCAK in G2/M to facilitate ciliogenesis in the following cell cycle

The paper identifies SCFFbxw5 as a regulator of MCAK levels during G2/M, showing that its loss impairs ciliogenesis in the subsequent G1 phase.

Proteomic analysis reveals Utf1 as a neurogenesis-associated new Sumo target

The paper identifies Utf1 as a new Sumo target involved in neurogenesis, showing sumoylation-dependent regulation of gene expression and chromatin binding.

Hsf1 is SUMOylated in the activated trimeric state

This study investigates how SUMOylation affects Hsf1 activity in vitro, finding that SUMOylation occurs in the activated trimeric state of Hsf1.

Pyrophosphate modulates stress responses via SUMOylation

This study shows that pyrophosphate modulates stress responses by inhibiting SUMOylation, affecting cold and heat stress sensitivity in plants and yeast.