S. Schuck

Reprograming of the ubiquitin ligase Ubr1 by intrinsically disordered Roq1 through cooperating multifunctional motifs

The paper identifies two cooperating motifs in Roq1 that modulate Ubr1 activity, enhancing ubiquitination of both folded and misfolded proteins during proteotoxic stress.

Phosphorylation of the GARP Subunit Vps53 by Snf1 Leads to the Formation of a Golgi-Mitochondria Contact Site (GoMiCS) in Yeast

Ice2 promotes ER membrane biogenesis in yeast by inhibiting the conserved lipin phosphatase complex

The paper identifies Ice2 as a regulator of ER membrane biogenesis in yeast by inhibiting the Nem1-Spo7 complex and Pah1 phosphatase.

ESCRT machinery mediates selective microautophagy of endoplasmic reticulum

This study identifies the ESCRT machinery and Nem1-Spo7 phosphatase complex as key components mediating micro-ER-phagy in yeast, distinguishing it from macro-ER-phagy.

Pyrophosphate modulates stress responses via SUMOylation

This study shows that pyrophosphate modulates stress responses by inhibiting SUMOylation, affecting cold and heat stress sensitivity in plants and yeast.

The proteasome biogenesis regulator Rpn4 cooperates with the unfolded protein response to promote resistance to endoplasmic reticulum stress

The paper identifies Rpn4 as a factor that enhances ER stress resistance by cooperating with the UPR in yeast, showing Rpn4 abundance increases through post-transcriptional and transcriptional mechanisms.