F. N. Papavasiliou

This paper develops a method to generate tumor-specific neoantigens using RNA editing, demonstrating its ability to create immunogenic epitopes that activate T cells and enhance immunotherapy potential.

The paper uses experimental and computational methods to classify VSG proteins in African trypanosomes, revealing structural and conformational diversity that contributes to immune evasion.

This study shows metacyclic and bloodstream form VSGs of African trypanosomes are structurally and immunologically similar.

This paper develops a trypanosome-derived vaccine platform (VAST) that elicits high-affinity antibodies against fentanyl, demonstrating protective immunity through single-cell RNAseq and crystallography.

The paper shows that immune responses to African trypanosome VSGs are focused on immunodominant epitopes, enabling immune evasion through epitope variation.

The paper shows that nanobodies induce membrane fission and remodeling in African trypanosomes by causing macromolecular crowding, leading to loss of motility and nanovesicle shedding.

This study identifies that the trypanosome VSGsur protein binds suramin, conferring drug resistance, and shows this interaction is critical for resistance.