Author

J. Zeelen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

C. E. Stebbins· 3 shared F. N. Papavasiliou· 3 shared M. van Straaten· 3 shared H. Hashemi· 2 shared A. Baumann· 1 shared A. Hempelmann· 1 shared A. Miller· 1 shared A. Svirina· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersMicrobiology

C. E. Stebbins

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structural and Immunological Similarities Between the Metacyclic and Bloodstream Form Variant Surface Glycoproteins of the African Trypanosome

M. Chandra, S. Dakovic, K. Foti, J. Zeelen, M. van Straaten, F. Aresta-Branco, E. Tihon, N. Luebbehusen, T. Ruppert, L. Glover, F. N. Papavasiliou, C. E. Stebbins

This study shows metacyclic and bloodstream form VSGs of African trypanosomes are structurally and immunologically similar.

bioRxiv · Sep 28, 2022Microbiology

An Epitope-Focused Trypanosome-Derived Vaccine Platform Elicits High-Affinity Antibodies and Immunity Against Fentanyl Effects

G. Triller, E. P. Vlachou, H. Hashemi, M. van Straaten, J. Zeelen, Y. Kelemen, C. Baehr, C. Marker, S. Ruf, A. Svirina, S. Kruse, A. Baumann, A. Miller, M. Bartel, M. Pravetoni, , J. P. Verdi

This paper develops a trypanosome-derived vaccine platform (VAST) that elicits high-affinity antibodies against fentanyl, demonstrating protective immunity through single-cell RNAseq and crystallography.

bioRxiv · May 2, 2022 · PreprintImmunology

A Parasite Coat Protein Binds Suramin to Confer Drug Resistance

J. Zeelen, M. van Straaten, J. Verdi, A. Hempelmann, H. Hashemi, K. Perez, P. D. Jeffrey, S. Haelg, N. Wiedemar, P. Maeser, F. N. Papavasiliou, C. E. Stebbins

This study identifies that the trypanosome VSGsur protein binds suramin, conferring drug resistance, and shows this interaction is critical for resistance.

bioRxiv · Jun 4, 2020 · PreprintMicrobiology