Author

N. G. Jones

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cell Biology· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Approach:microscopy & imaging analysis· 2 Organism:Arabidopsis· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

M. Engstler· 5 shared J. C. Mottram· 3 shared A. J. Wilkinson· 2 shared C. Batram· 2 shared F. Calderon· 2 shared M. Bakari-Soale· 2 shared R. Gabarro· 2 shared V. Geoghegan· 2 shared

Activity by Year

2021-2023 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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5 shared papersMicrobiology

M. Engstler

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

The dual role of the 16mer motif within the 3' untranslated region of the variant surface glycoprotein of Trypanosoma brucei

M. Bakari-Soale, C. Batram, H. Zimmermann, N. G. Jones, M. Engstler

This study investigates the dual role of a conserved 16mer motif in the 3' UTR of Trypanosoma brucei VSG genes, showing it is essential for transcript stability but not required for VSG silencing or differentiation.

bioRxiv · Dec 21, 2023 · PreprintCell Biology

Bromodomain Factor 5 as a Target for Antileishmanial Drug Discovery

C. N. Russell, J. L. Carter, J. M. Borgia, J. Bush, F. Calderon, R. Gabarro, S. J. Conway, J. C. Mottram, A. J. Wilkinson, N. G. Jones

This paper identifies LdBDF5 as a potential drug target for antileishmanial therapy by showing its interaction with human bromodomain inhibitors and demonstrating antipromastigote activity of SGC-CBP30.

bioRxiv · Aug 21, 2023Biochemistry

Continuous endosomes form functional subdomains and orchestrate rapid membrane trafficking in trypanosomes

F. Link, A. Borges, O. Karo, M. Jungblut, T. Mueller, E. Meyer-Natus, T. Krueger, S. Sachs, N. G. Jones, M. Morphew, M. Sauer, C. Stigloher, J. R. McIntosh, M. Engstler

The paper investigates the endosomal system in Trypanosoma brucei, revealing it as a continuous membrane system rather than distinct compartments, enabling rapid membrane trafficking.

bioRxiv · Jul 20, 2023Cell Biology

Bromodomain factor 5 is an essential transcriptional regulator of the Leishmania genome.

N. G. Jones, V. Geoghegan, G. Moore, J. B. T. Carnielli, K. Newling, F. Calderon, R. Gabarro, J. Martin, R. Prinjha, I. Rioja, A. J. Wilkinson, J. C. Mottram

This study identifies BDF5 as essential for Leishmania gene expression and survival by analyzing its role in chromatin interpretation and transcriptional regulation.

bioRxiv · Sep 29, 2021Cell Biology

Protein kinase signalling at the Leishmania kinetochore captured by XL-BioID

V. Geoghegan, N. G. Jones, A. Dowle, J. C. Mottram

The paper develops XL-BioID to study kinase signaling at the Leishmania kinetochore, identifying a novel protein and characterizing phosphosites during the cell cycle.

bioRxiv · Jul 8, 2021 · PreprintBiochemistry

The nucleolar DExD/H protein Hel66 is involved in ribosome biogenesis in Trypanosoma brucei

M. Bakari-Soale, N. J. Ikenge, M. Scheibe, F. Butter, N. G. Jones, S. Kramer, M. Engstler

This study identifies Hel66, a DExD/H box helicase, as essential for ribosome biogenesis in Trypanosoma brucei, showing its role in translation and rRNA processing.

bioRxiv · Jun 11, 2021Microbiology

Toxoplasma bradyzoites exhibit physiological plasticity of calcium and energy stores controlling motility and egress.

Y. Fu, K. M. Brown, N. G. Jones, S. N. J. Moreno, L. D. Sibley

This study shows that Toxoplasma bradyzoites have reduced calcium and energy stores, limiting their motility and egress, but they can rapidly restore these stores upon release from cysts.

bioRxiv · May 17, 2021Microbiology

Endoplasmic reticulum-targeting but not translation is required for mRNA balancing in trypanosomes

E. O. Aroko, M. B. Soale, C. Batram, N. G. Jones, M. Engstler

This study shows that ER targeting, not translation, regulates VSG mRNA levels in trypanosomes, suggesting ER feedback controls mRNA amounts to prevent secretory pathway overload.

bioRxiv · May 5, 2021 · PreprintMicrobiology

Nanobody Mediated Macromolecular Crowding Induces Membrane Fission and Remodeling in the African Trypanosome

A. Hempelmann, L. Hartleb, M. Van Straaten, H. Hashemi, J. P. Zeelen, F. N. Papavasiliou, M. Engstler, C. E. Stebbins, N. G. Jones

The paper shows that nanobodies induce membrane fission and remodeling in African trypanosomes by causing macromolecular crowding, leading to loss of motility and nanovesicle shedding.

bioRxiv · Jan 13, 2021Microbiology