Author

C. E. Stebbins

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:Arabidopsis· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Organism:mouse· 2 Assay:protein structure· 2

Frequent Co-Authors

F. N. Papavasiliou· 6 shared M. van Straaten· 5 shared E. P. Vlachou· 3 shared F. Aresta-Branco· 3 shared H. Hashemi· 3 shared J. Zeelen· 3 shared A. Gkeka· 2 shared A. Hempelmann· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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6 shared papersMicrobiology

F. N. Papavasiliou

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6 papers

Recent·Most cited

A Structural Classification of the Variant Surface Glycoproteins of the African Trypanosome

S. Dakovic, J. P. Zeelen, A. Gkeka, M. Chandra, C. Foti, M. van Straaten, E. P. Vlachou, F. Aresta-Branco, F. N. Papavasiliou, J. Verdi, C. E. Stebbins

The paper uses experimental and computational methods to classify VSG proteins in African trypanosomes, revealing structural and conformational diversity that contributes to immune evasion.

bioRxiv · Feb 4, 2023 · PreprintMicrobiology

Structural and Immunological Similarities Between the Metacyclic and Bloodstream Form Variant Surface Glycoproteins of the African Trypanosome

M. Chandra, S. Dakovic, K. Foti, J. Zeelen, M. van Straaten, F. Aresta-Branco, E. Tihon, N. Luebbehusen, T. Ruppert, L. Glover, F. N. Papavasiliou, C. E. Stebbins

This study shows metacyclic and bloodstream form VSGs of African trypanosomes are structurally and immunologically similar.

bioRxiv · Sep 28, 2022Microbiology

An Epitope-Focused Trypanosome-Derived Vaccine Platform Elicits High-Affinity Antibodies and Immunity Against Fentanyl Effects

G. Triller, E. P. Vlachou, H. Hashemi, M. van Straaten, J. Zeelen, Y. Kelemen, C. Baehr, C. Marker, S. Ruf, A. Svirina, S. Kruse, A. Baumann, A. Miller, M. Bartel, M. Pravetoni, , J. P. Verdi

This paper develops a trypanosome-derived vaccine platform (VAST) that elicits high-affinity antibodies against fentanyl, demonstrating protective immunity through single-cell RNAseq and crystallography.

bioRxiv · May 2, 2022 · PreprintImmunology

Immunodominant surface epitopes power immune evasion in the African trypanosome

A. Gkeka, F. Aresta-Branco, G. Triller, E. P. Vlachou, M. Lilic, P. D. B. Olinares, K. Perez, B. Chait, R. Blatnik, T. Ruppert, C. E. Stebbins, F. N. Papavasiliou

The paper shows that immune responses to African trypanosome VSGs are focused on immunodominant epitopes, enabling immune evasion through epitope variation.

bioRxiv · Jul 20, 2021Immunology

Nanobody Mediated Macromolecular Crowding Induces Membrane Fission and Remodeling in the African Trypanosome

A. Hempelmann, L. Hartleb, M. Van Straaten, H. Hashemi, J. P. Zeelen, F. N. Papavasiliou, M. Engstler, C. E. Stebbins, N. G. Jones

The paper shows that nanobodies induce membrane fission and remodeling in African trypanosomes by causing macromolecular crowding, leading to loss of motility and nanovesicle shedding.

bioRxiv · Jan 13, 2021Microbiology

A Parasite Coat Protein Binds Suramin to Confer Drug Resistance

J. Zeelen, M. van Straaten, J. Verdi, A. Hempelmann, H. Hashemi, K. Perez, P. D. Jeffrey, S. Haelg, N. Wiedemar, P. Maeser, F. N. Papavasiliou, C. E. Stebbins

This study identifies that the trypanosome VSGsur protein binds suramin, conferring drug resistance, and shows this interaction is critical for resistance.

bioRxiv · Jun 4, 2020 · PreprintMicrobiology