Apremilast prevents blistering in human epidermis by stabilization of keratinocyte adhesion in pemphigus.
A. M. Sigmund, M. Winkler, S. Engelmayer, D. T. Egu, D. Kugelmann, M. Y. Radeva, F. C. Bayerbach, S. Kotschi, S. Yeruva, E. Schmidt, A. S. Yazdi, K. Ghoreschi, F. Vielmuth, J. Waschke
This study shows apremilast stabilizes keratinocyte adhesion in pemphigus by phosphorylating plakoglobin at serine 665, preventing blistering without affecting desmoglein depletion or binding.
bioRxiv · Feb 7, 2022Cell Biology