J. Waschke

The myocyte Nfe2l1-ubiquitin-proteasome system controls muscle fiber type and obesity-induced insulin resistance

This study shows that Nfe2l1 regulates skeletal muscle proteostasis and function, with its loss causing muscle fiber type switching and insulin resistance in high-fat diet conditions.

Catalytic antibodies in arrhythmogenic cardiomyopathy patients cleave desmoglein 2 and N-cadherin and impair cardiomyocyte cohesion

This study shows that catalytic autoantibodies in arrhythmogenic cardiomyopathy patients cleave desmoglein 2 and N-cadherin, impairing cardiomyocyte cohesion through p38MAPK activation.

Soluble VE-cadherin disrupts endothelial barrier function via VE-PTP/RhoA signalling

This study shows that soluble VE-cadherin fragments disrupt endothelial barrier function by interfering with VE-PTP/RhoA signaling in both in vitro and in vivo models.

EGFR inhibition led ROCK activation enhances desmosome assembly and cohesion in cardiomyocytes

The paper shows EGFR inhibition activates ROCK, enhancing desmosome assembly and cardiomyocyte cohesion in a murine model of arrhythmogenic cardiomyopathy.

Apremilast prevents blistering in human epidermis by stabilization of keratinocyte adhesion in pemphigus.

This study shows apremilast stabilizes keratinocyte adhesion in pemphigus by phosphorylating plakoglobin at serine 665, preventing blistering without affecting desmoglein depletion or binding.

Clustering of desmosomal cadherins by desmoplakin is essential for cell-cell adhesion

This study shows that desmoplakin is essential for clustering desmosomal cadherins and forming functional desmosomes, which are critical for cell-cell adhesion.

The actin binding protein α-adducin modulates desmosomal turnover and plasticity

This study shows that α-adducin modulates desmosome turnover and plasticity in response to mechanical stress by affecting the mobility of desmosomal molecules.