Author

M. Hiermaier

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:development & morphogenesis· 2 Organism:mouse· 2

Frequent Co-Authors

J. Waschke· 5 shared C. Schinner· 2 shared C. Stüdle· 2 shared F. Vielmuth· 2 shared M. Shoykhet· 2 shared M.-T. Wanuske· 2 shared S. Yeruva· 2 shared V. Spindler· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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5 shared papersCell Biology

J. Waschke

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Author profile →

5 papers

Recent·Most cited

Catalytic antibodies in arrhythmogenic cardiomyopathy patients cleave desmoglein 2 and N-cadherin and impair cardiomyocyte cohesion

S. Yeruva, K. Stangner, A. Jungwirth, M. Hiermaier, M. Shoykhet, D. Kugelmann, M. Hertl, S. Egami, N. Ishii, H. Koga, T. Hashimoto, M. Weis, B. M. Beckmann, R. Biller, D. Schuettler, , J. Waschke

This study shows that catalytic autoantibodies in arrhythmogenic cardiomyopathy patients cleave desmoglein 2 and N-cadherin, impairing cardiomyocyte cohesion through p38MAPK activation.

bioRxiv · Feb 8, 2023Cell Biology

Soluble VE-cadherin disrupts endothelial barrier function via VE-PTP/RhoA signalling

J.-L. Knop, N. Burkard, M. Danesh, T. Dandekar, M. Srivastava, M. Hiermaier, J. Waschke, S. Flemming, N. Schlegel

This study shows that soluble VE-cadherin fragments disrupt endothelial barrier function by interfering with VE-PTP/RhoA signaling in both in vitro and in vivo models.

bioRxiv · Oct 17, 2022 · PreprintPhysiology

EGFR inhibition led ROCK activation enhances desmosome assembly and cohesion in cardiomyocytes

M. Shoykhet, O. Dervishi, P. Menauer, M. Hiermaier, C. Osterloh, R. Ludwig, J. Waschke, S. Yeruva

The paper shows EGFR inhibition activates ROCK, enhancing desmosome assembly and cardiomyocyte cohesion in a murine model of arrhythmogenic cardiomyopathy.

bioRxiv · Apr 27, 2022 · PreprintCell Biology

Clustering of desmosomal cadherins by desmoplakin is essential for cell-cell adhesion

M.-T. Wanuske, D. Brantschen, C. Schinner, C. Stüdle, E. Walter, M. Hiermaier, F. Vielmuth, J. Waschke, V. Spindler

This study shows that desmoplakin is essential for clustering desmosomal cadherins and forming functional desmosomes, which are critical for cell-cell adhesion.

bioRxiv · Apr 6, 2020Cell Biology

The actin binding protein α-adducin modulates desmosomal turnover and plasticity

M. Hiermaier, F. Kliewe, C. Schinner, C. Stüdle, I. P. Maly, M.-T. Wanuske, V. Rötzer, N. Endlich, F. Vielmuth, J. Waschke, V. Spindler

This study shows that α-adducin modulates desmosome turnover and plasticity in response to mechanical stress by affecting the mobility of desmosomal molecules.

bioRxiv · Oct 1, 2019Cell Biology