Author

D. Kugelmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

J. Waschke· 3 shared M. Hiermaier· 2 shared M. Y. Radeva· 2 shared S. Yeruva· 2 shared A. Garcia Ponce· 1 shared A. Jungwirth· 1 shared A. K. E. Horn· 1 shared A. M. Sigmund· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCell Biology

J. Waschke

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Author profile →

3 papers

Recent·Most cited

Dsg2 truncation causes a lethal barrier breakdown in mice

D. Kugelmann, E. S. Butz, A. Garcia Ponce, M. Y. Radeva, J. Neubauer, M. Hiermaier, C. Siadjeu, N. Burkard, D. Egu, A. K. E. Horn, C. Schmitz, K. S. Vuopala, O. Kuismin, N. Schlegel, J. Waschke

This study shows that a DSG2 mutation causing Dsg2 truncation leads to a lethal intestinal barrier defect and a skewed IL17 response in mice, similar to Crohn's disease.

bioRxiv · Jul 1, 2024 · PreprintCell Biology

Catalytic antibodies in arrhythmogenic cardiomyopathy patients cleave desmoglein 2 and N-cadherin and impair cardiomyocyte cohesion

S. Yeruva, K. Stangner, A. Jungwirth, M. Hiermaier, M. Shoykhet, D. Kugelmann, M. Hertl, S. Egami, N. Ishii, H. Koga, T. Hashimoto, M. Weis, B. M. Beckmann, R. Biller, D. Schuettler, , J. Waschke

This study shows that catalytic autoantibodies in arrhythmogenic cardiomyopathy patients cleave desmoglein 2 and N-cadherin, impairing cardiomyocyte cohesion through p38MAPK activation.

bioRxiv · Feb 8, 2023Cell Biology

Apremilast prevents blistering in human epidermis by stabilization of keratinocyte adhesion in pemphigus.

A. M. Sigmund, M. Winkler, S. Engelmayer, D. T. Egu, D. Kugelmann, M. Y. Radeva, F. C. Bayerbach, S. Kotschi, S. Yeruva, E. Schmidt, A. S. Yazdi, K. Ghoreschi, F. Vielmuth, J. Waschke

This study shows apremilast stabilizes keratinocyte adhesion in pemphigus by phosphorylating plakoglobin at serine 665, preventing blistering without affecting desmoglein depletion or binding.

bioRxiv · Feb 7, 2022Cell Biology