Targeting HIV Env immunogens to B cell follicles in non-human primates through immune complex or protein nanoparticle formulations
J. T. Martin, C. T. Cottrell, A. Antanasijevic, D. G. Carnathan, B. J. Cossette, C. A. Enemuo, E. H. Gebru, Y. Choe, F. Viviano, T. Tokatlian, K. M. Cirelli, G. Ueda, J. Copps, T. Schiffner, S. Menis, , D. J. Irvine
This study shows that HIV Env immunogens can be concentrated in B cell follicles using immune complexes or protein nanoparticles, enhancing their localization in lymph nodes and potentially improving immune responses.
bioRxiv · Feb 19, 2020Immunology