Author

K. M. Cirelli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 5

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Organism:rat· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Assay:cryo-EM· 1

Frequent Co-Authors

D. G. Carnathan· 5 shared G. Silvestri· 5 shared S. Crotty· 5 shared A. B. Ward· 4 shared C. A. Cottrell· 4 shared C. A. Enemuo· 4 shared D. J. Irvine· 4 shared W. R. Schief· 4 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersImmunology

D. G. Carnathan

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Focusing antibody responses to the fusion peptide in rhesusmacaques

C. A. Cottrell, P. P. Pratap, K. M. Cirelli, D. G. Carnathan, C. A. Enemuo, A. Antansijevic, G. Ozorowski, L. M. Sewall, H. Gao, K. M. Greene, J. D. Allen, J. T. Ngo, Y. Choe, B. Nogal, M. Silva, , A. B. Ward

This study uses continuous immunogen delivery in rhesus macaques to focus antibody responses on the HIV fusion peptide, identifying key residues for vaccine design.

bioRxiv · Jun 26, 2023 · PreprintImmunology

Long-lasting germinal center responses to a priming immunization with continuous proliferation and somatic mutation

J. H. Lee, H. J. Sutton, C. A. Cottrell, I. Phung, G. Ozorowski, L. M. Sewall, R. Nedellec, C. Nakao, M. Silva, S. T. Richey, J. L. Torres, W.-H. Lee, E. Georgeson, M. Kubitz, S. Hodges, , S. Crotty

This study shows that germinal center B cells can persist and continue to mutate for 29 weeks after a single immunization, leading to long-lasting antibody responses.

bioRxiv · Dec 20, 2021 · PreprintImmunology

From Structure to Sequence: Identification of polyclonal antibody families using cryoEM

A. Antanasijevic, C. A. Bowman, R. N. Kirchdoerfer, C. A. Cottrell, G. Ozorowski, A. A. Upadhyay, K. M. Cirelli, D. G. Carnathan, C. A. Enemuo, L. M. Sewall, B. Nogal, F. Zhao, B. Groschel, W. R. Schief, D. Sok, , A. B. Ward

This paper uses cryoEM and next-generation sequencing to identify monoclonal antibodies from polyclonal sera and validate their antigen-binding properties.

bioRxiv · Apr 13, 2021 · PreprintImmunology

Targeting HIV Env immunogens to B cell follicles in non-human primates through immune complex or protein nanoparticle formulations

J. T. Martin, C. T. Cottrell, A. Antanasijevic, D. G. Carnathan, B. J. Cossette, C. A. Enemuo, E. H. Gebru, Y. Choe, F. Viviano, T. Tokatlian, K. M. Cirelli, G. Ueda, J. Copps, T. Schiffner, S. Menis, , D. J. Irvine

This study shows that HIV Env immunogens can be concentrated in B cell follicles using immune complexes or protein nanoparticles, enhancing their localization in lymph nodes and potentially improving immune responses.

bioRxiv · Feb 19, 2020Immunology

Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance

K. M. Cirelli, D. G. Carnathan, B. Nogal, O. L. Rodriguez, J. T. Martin, A. A. Upadhyay, C. A. Enemuo, E. H. Gebru, Y. Choe, F. Viviano, C. Nakao, M. Pauthner, S. Reiss, C. A. Cottrell, R. Bastidas, , S. Crotty

This study shows that slow delivery immunization in rhesus macaques increases HIV-neutralizing antibody titers and germinal center responses by modulating immunodominance.

bioRxiv · Oct 1, 2018Immunology