Author

C. A. Enemuo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 3 Organism:rat· 3 Research Focus:benchmarking· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Organism:non-human primate· 1

Frequent Co-Authors

D. G. Carnathan· 5 shared G. Silvestri· 5 shared K. M. Cirelli· 4 shared S. Crotty· 4 shared A. B. Ward· 3 shared B. Nogal· 3 shared C. A. Cottrell· 3 shared D. J. Irvine· 3 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersImmunology

D. G. Carnathan

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5 papers

Recent·Most cited

A novel HIV triple broadly neutralizing antibody (bNAb) combination-based passive immunization of infant rhesus macaques achieves durable protective plasma neutralization levels and mediates anti-viral effector functions.

S. Dankwa, C. Kosman, M. Dennis, E. E. Giorgi, K. Vuong, I. Pahountis, A. Garza, J. McCarthy, B. T. Mayer, J. T. Ngo, C. A. Enemuo, D. G. Carnathan, S. Stanfield-Oakley, S. J. Berendam, C. Weinbaum, , R. Goswami

This study evaluates a triple bNAb combination in infant rhesus macaques, showing durable neutralization and effector functions with high predicted prevention efficacy against HIV strains.

PLOS ONE · Nov 11, 2024Peer-reviewedImmunology

Focusing antibody responses to the fusion peptide in rhesusmacaques

C. A. Cottrell, P. P. Pratap, K. M. Cirelli, D. G. Carnathan, C. A. Enemuo, A. Antansijevic, G. Ozorowski, L. M. Sewall, H. Gao, K. M. Greene, J. D. Allen, J. T. Ngo, Y. Choe, B. Nogal, M. Silva, , A. B. Ward

This study uses continuous immunogen delivery in rhesus macaques to focus antibody responses on the HIV fusion peptide, identifying key residues for vaccine design.

bioRxiv · Jun 26, 2023 · PreprintImmunology

From Structure to Sequence: Identification of polyclonal antibody families using cryoEM

A. Antanasijevic, C. A. Bowman, R. N. Kirchdoerfer, C. A. Cottrell, G. Ozorowski, A. A. Upadhyay, K. M. Cirelli, D. G. Carnathan, C. A. Enemuo, L. M. Sewall, B. Nogal, F. Zhao, B. Groschel, W. R. Schief, D. Sok, , A. B. Ward

This paper uses cryoEM and next-generation sequencing to identify monoclonal antibodies from polyclonal sera and validate their antigen-binding properties.

bioRxiv · Apr 13, 2021 · PreprintImmunology

Targeting HIV Env immunogens to B cell follicles in non-human primates through immune complex or protein nanoparticle formulations

J. T. Martin, C. T. Cottrell, A. Antanasijevic, D. G. Carnathan, B. J. Cossette, C. A. Enemuo, E. H. Gebru, Y. Choe, F. Viviano, T. Tokatlian, K. M. Cirelli, G. Ueda, J. Copps, T. Schiffner, S. Menis, , D. J. Irvine

This study shows that HIV Env immunogens can be concentrated in B cell follicles using immune complexes or protein nanoparticles, enhancing their localization in lymph nodes and potentially improving immune responses.

bioRxiv · Feb 19, 2020Immunology

Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance

K. M. Cirelli, D. G. Carnathan, B. Nogal, O. L. Rodriguez, J. T. Martin, A. A. Upadhyay, C. A. Enemuo, E. H. Gebru, Y. Choe, F. Viviano, C. Nakao, M. Pauthner, S. Reiss, C. A. Cottrell, R. Bastidas, , S. Crotty

This study shows that slow delivery immunization in rhesus macaques increases HIV-neutralizing antibody titers and germinal center responses by modulating immunodominance.

bioRxiv · Oct 1, 2018Immunology