Author

O. L. Rodriguez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 3 Organism:human· 3 Research Focus:variant calling· 3 Research Focus:clustering· 2 Approach:deep learning· 2 Research Focus:gene regulatory network inference· 2 Assay:long-read sequencing· 2

Frequent Co-Authors

C. T. Watson· 4 shared G. Yaari· 3 shared A. Peres· 2 shared D. Tieri· 2 shared M. L. Smith· 2 shared A. A. Upadhyay· 1 shared A. B. Ward· 1 shared A. Charney· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersImmunology

C. T. Watson

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5 papers

Recent·Most cited

Ultrasensitive allele inference from immune repertoire sequencing data with MiXCR

A. Mikelov, G. Nefedev, A. Tashkeev, O. L. Rodriguez, D. A. Ortmans, V. Skatova, M. Izraelson, A. Davydov, S. Poslavsky, S. Rahmouni, C. T. Watson, D. Chudakov, S. D. Boyd, D. A. Bolotin

The paper introduces an algorithm for ultra-sensitive allele inference from immune repertoire sequencing data, demonstrating its accuracy and application in diverse populations.

Genome Research · Oct 21, 2024Peer-reviewedImmunology

Resolving haplotype variation and complex genetic architecture in the human immunoglobulin kappa chain locus in individuals of diverse ancestry

E. Engelbrecht, O. L. Rodriguez, K. Shields, S. Schulze, D. Tieri, U. Jana, G. Yaari, W. Lees, M. L. Smith, C. T. Watson

The paper uses long-read sequencing to resolve haplotype variation and genetic architecture in the human IGK locus across diverse ancestries, identifying novel variants and population-specific allele frequencies.

bioRxiv · Oct 23, 2023Immunology

IGHV allele similarity clustering improves genotype inference from adaptive immune receptor repertoire sequencing data

A. Peres, W. D. Lees, O. L. Rodriguez, N. Y. Lee, P. Polak, R. Hope, M. Kedmi, A. M. Collins, M. Ohlin, S. H. Kleinstein, C. Watson, G. Yaari

The paper introduces a new V allele naming scheme and genotype inference method for adaptive immune receptor sequencing, validated with genomic long read data and implemented in an R package.

bioRxiv · Dec 26, 2022 · PreprintImmunology

FLAIRR-seq: A novel method for single molecule resolution of near full-length immunoglobulin heavy chain repertoires

E. E. Ford, D. Tieri, O. L. Rodriguez, N. J. Francoeur, J. Soto, J. T. Kos, A. Peres, W. S. Gibson, C. A. Silver, G. Deikus, E. Hudson, C. R. Woolley, N. Beckmann, A. Charney, T. C. Mitchell, , M. L. Smith

FLAIRR-seq provides high-resolution, single-molecule characterization of immunoglobulin heavy chain repertoires, including constant region features, and identifies novel alleles.

bioRxiv · Sep 24, 2022 · PreprintImmunology

Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance

K. M. Cirelli, D. G. Carnathan, B. Nogal, O. L. Rodriguez, J. T. Martin, A. A. Upadhyay, C. A. Enemuo, E. H. Gebru, Y. Choe, F. Viviano, C. Nakao, M. Pauthner, S. Reiss, C. A. Cottrell, R. Bastidas, , S. Crotty

This study shows that slow delivery immunization in rhesus macaques increases HIV-neutralizing antibody titers and germinal center responses by modulating immunodominance.

bioRxiv · Oct 1, 2018Immunology