Author

F. Xian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:deep learning· 2 Approach:experimental assay· 2 Assay:metagenomics· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

M. Schmidt· 3 shared D. Aguanno· 2 shared D. Gomez-Varela· 2 shared D. Haller· 2 shared E. Urbauer· 2 shared A. M. Barry· 1 shared A. Metwaly· 1 shared A. Vazquez· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersMicrobiology

M. Schmidt

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Ultra-sensitivity metaproteomics redefines the gut dark metaproteome, uncovering host-microbiome interactions and drug targets in intestinal inflammatory diseases.

F. Xian, M. Brenek, C. Krisp, D. Aguanno, E. Urbauer, T. Srikumar, R. K. Ravi Kumar, Q. Liu, A. M. Barry, B. Ma, J. Krieger, D. Haller, M. Schmidt, D. Gomez Varela

The paper introduces uMetaP, an ultra-sensitive metaproteomic method that enhances detection of the gut dark metaproteome and identifies drug targets in intestinal inflammatory diseases.

bioRxiv · Apr 22, 2024 · PreprintMicrobiology

Mitochondrial perturbation in the intestine causes microbiota-dependent injury and gene signatures discriminative of inflammatory disease

E. Urbauer, D. Aguanno, N. Mindermann, H. Omer, A. Metwaly, T. Krammel, T. Faro, M. Remke, S. Reitmeier, S. Bärthel, J. Kersting, Z. Huang, F. Xian, M. Schmidt, D. Saur, , D. Haller

The paper shows mitochondrial dysfunction in intestinal epithelium leads to microbiota-dependent injury and identifies gene signatures that distinguish active from inactive inflammation in IBD.

bioRxiv · Jul 27, 2023 · PreprintMicrobiology

Expanding the Characterization of Microbial Ecosystems using DIA-PASEF Metaproteomics

D. Gomez-Varela, F. Xian, S. Grundtner, J. R. Sondermann, G. Carta, M. Schmidt

This study introduces a DIA-PASEF metaproteomic workflow that enhances protein and taxon identification in mouse gut microbiota and host proteome, revealing more functional pathways and host-microbiome interactions in a chronic pain model.

bioRxiv · Mar 16, 2023 · PreprintMicrobiology

Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis

N. Kiweler, C. Delbrouck, V. I. Pozdeev, L. Neises, L. Soriano-Baguet, K. Eiden, F. Xian, M. Benzarti, L. Haase, E. Koncina, M. Schmoetten, C. Jaeger, M. Z. Noman, A. Vazquez, B. Janji, , J. Meiser

This study identifies mitochondrial one-carbon metabolism as a key driver of cancer cell migration and metastasis independent of proliferation.

Nature Communications · May 16, 2022Peer-reviewedCancer Biology