C. Krisp

Ultra-sensitivity metaproteomics redefines the gut dark metaproteome, uncovering host-microbiome interactions and drug targets in intestinal inflammatory diseases.

The paper introduces uMetaP, an ultra-sensitive metaproteomic method that enhances detection of the gut dark metaproteome and identifies drug targets in intestinal inflammatory diseases.

Proteomic adaptations in the kidney reveal orchestration of local and secreted antimicrobial peptides in human pyelonephritis

This study identifies proteomic adaptations in human pyelonephritis, revealing elevated antimicrobial peptides and their potential protective role against systemic inflammation.

Multiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level

This study identifies subtype-specific proteome and N-glycan alterations in medulloblastoma that may serve as therapeutic targets.

Comparative assessment of quantification methods for tumor tissue phosphoproteomics

This study compares quantification methods for tumor tissue phosphoproteomics and finds TMT offers highest precision, spike-in-SILAC balances features best, and LFQ provides most identifications.

Centrosome-dependent microtubule organization sets the conditions for axon formation

This study shows that centrosome-dependent microtubule organization is essential for axon formation by promoting stable microtubule accumulation in the growing axon.

N-terminal VP1 truncations favor T=1 norovirus-like particles

The paper identifies N-terminal VP1 truncations as a cause for T=1 norovirus-like particle formation and discusses implications for vaccine and biotechnological applications.

An improved comprehensive strategy for deep and quantitative N-glycomics based on optimization of sample preparation, isotope-based data quality control and quantification, new N-glycan libraries and new algorithms

The paper presents an improved strategy for deep N-glycomics with optimized sample prep, isotope-based QC, new libraries, and algorithms, but the manuscript was withdrawn due to incomplete data.

Murine cytomegaloviruses m139 targets DDX3 to curtail interferon production and promote viral replication

This paper identifies m139 as a viral gene that targets DDX3 to suppress interferon production and enhance viral replication in macrophages and endothelial cells.

Proteome analysis of human visceral and subcutaneous adipocytes identifies depot-specific heterogeneity at metabolic control points

The paper identifies depot-specific proteomic differences in human adipocytes from visceral, subcutaneous, and gluteal-femoral adipose tissue, revealing metabolic heterogeneity.