Fabiana Tedeschi

Design of novel synthetic promoters to tune gene expression in T cells

The paper designs synthetic promoters that respond to TFs differentially expressed in activated and exhausted T cells, enabling functional state classification and dynamic gene expression control.

Resource-aware construct design in mammalian cells

The paper quantifies resource load from genetic constructs in mammalian cells and provides a framework for designing more efficient synthetic circuits.

Characterization, modelling and mitigation of gene expression burden in mammalian cells

This study identifies gene expression burden in mammalian cells and introduces miRNA-based circuits to mitigate it, improving synthetic circuit performance.