The Cul3 ubiquitin ligase engages Insomniac as an adaptor to impact sleep and synaptic homeostasis
Qiuling Li, Kayla Y. Lim, Raad Altawell, Faith Verderose, Xiling Li, Wanying Dong, Joshua C. Martinez, Dion K. Dickman, Nicholas Stavropoulos
This paper identifies Insomniac as a Cul3 adaptor protein that regulates sleep and synaptic homeostasis in Drosophila, linking Cul3 dysfunction to autism and schizophrenia.
PLoS Genetics · Jan 22, 2025Peer-reviewedNeuroscience