Tissue-specific effects of dietary protein on cellular senescence are mediated by branched-chain amino acids
Mariah F. Calubag, Ismail Ademi, Isaac Grunow, Lucia Breuer, Reji Babygirija, Penelope Lialios, Sandra M. Le, Dennis M. Minton, Michelle M. Sonsalla, Julia A. Illiano, Bailey A. Knopf, Fan Xiao, Adam R. Konopka, David A. Harris, Dudley W. Lamming
This study shows that dietary BCAA restriction mitigates metabolic issues and cellular senescence in mice, with tissue-specific effects observed.
Aging Cell · Jul 28, 2025Peer-reviewedPhysiology