David A. Harris

This study shows that folic acid polyglutamylation activates MAP2K5 signaling to promote adipocyte lipid breakdown, revealing a novel role for folate in lipid homeostasis.

The paper shows that in female mice, carbohydrate quality affects metabolic and neurological responses to low protein diets, but not in males.

This study shows that sleeve gastrectomy improves metabolic health, cognition, and Alzheimer's pathology in 3xTg-AD mice by modulating autophagy and insulin signaling.

This study examines the effects of restricting individual branched-chain amino acids on Alzheimer's disease progression in 3xTg mice, finding sex-specific cognitive and metabolic benefits.

This study shows that sleeve gastrectomy in lean mice improves metabolic health and protects against future obesity without weight loss.

This study shows that a low protein diet enhances metabolic health and weight loss in mice after sleeve gastrectomy, challenging current high-protein dietary recommendations.

This study shows that fasting, not just calorie reduction, is necessary for many benefits of caloric restriction in 3xTg mice with Alzheimer's disease.

This study shows that dietary BCAA restriction mitigates metabolic issues and cellular senescence in mice, with tissue-specific effects observed.

The paper identifies heritable genetic variants in cancer genes that associate with both cancer risk and anthropometric traits in a large cohort.