Genome editing of marsupial RSX reveals conserved and divergent principles in mammalian X-inactivation
Aurélien Courtois, Sergio Menchero, Sugako Ogushi, Wazeer Varsally, S. M. Wood, Fanny Decarpentrie, Riko Yoshimi, Aki Shiraishi, Kenichi Inoue, Takaya Abe, John L. VandeBerg, Daniel M. Snell, Hiroshi Kiyonari, James M. A. Turner
This study uses CRISPR-Cas9 in opossums to show RSX is required for initiating X-inactivation, with divergent Polycomb regulation compared to eutherians.
bioRxiv · Jul 7, 2026 · PreprintGenomics