Wazeer Varsally

This study uses CRISPR-Cas9 in opossums to show RSX is required for initiating X-inactivation, with divergent Polycomb regulation compared to eutherians.

The paper generates isogenic hiPSCs with controlled sex chromosomes to study sex differences and X-haploinsufficiency effects on gene expression.

This study generates the first single-cell transcriptomic atlas of marsupial gastrulation and early organogenesis, revealing accelerated transcriptional programs and novel tissues associated with developmental heterochrony.

This study identifies Y-chromosome gene functions in mouse spermatogenesis by generating Y-deletion models and analyzing gene effects on fertility.

This study shows sex chromosomes significantly shape the transcriptional landscape of preimplantation mouse embryos through various mechanisms including Y chromosome effects, X chromosome dosage, imprinting, and Xist.

This paper reports genome-wide ChIP data showing Upf1 associates with active genes in S. pombe, correlating with Pol II transcription and mRNA levels, and reveals transcriptional defects in Upf1-deficient cells.

The paper identifies a novel enhancer that regulates Bdnf expression in developing neurons, increasing mRNA levels and promoting neuronal differentiation and dendritogenesis.