Takaya Abe

Ductal myofibroblasts reactivate contractile program to stabilize alveolar architecture during lung regeneration

The paper identifies ductal myofibroblasts as critical for maintaining alveolar structure during lung regeneration through reactivation of a contractile program.

Hypothermic Conditions Impair GnRH Pulse Generator Activity and Gametogenesis

This study shows hypothermia, not hypometabolism, suppresses reproductive activity in mice by reducing arcuate kisspeptin neuron activity during energy-saving conditions.

Genome editing of marsupial RSX reveals conserved and divergent principles in mammalian X-inactivation

This study uses CRISPR-Cas9 in opossums to show RSX is required for initiating X-inactivation, with divergent Polycomb regulation compared to eutherians.

Plagl2 unlocks the latent regenerative potential of Müller glia in the adult mouse retina

This study shows that Plagl2 reprograms adult mouse Müller glia into a progenitor-like state with both proliferative and neurogenic capabilities, enhancing retinal regeneration.

Ex vivo live imaging unveils the dynamics of oocyte formation in mice

This study uses ex vivo live imaging to observe oocyte formation dynamics in mice, revealing blebbing activity during mitosis-to-meiosis transition and no organelle transfer between germ cells.

Conserved interhemispheric morphogenesis in amniotes preceded the evolution of the corpus callosum

The paper shows that interhemispheric remodeling, a precursor to corpus callosum formation, is conserved in non-mammalian amniotes and plays a role in forming similar structures in reptiles and birds.

Submedius Thalamus Modulates Orbitofrontal Cortex Representations During Maternal Behavior in Mice

The paper identifies the submedius thalamus (SMT) as a presynaptic partner of the orbitofrontal cortex (OFC) in mice, showing its role in modulating maternal behavior through experience-dependent plasticity.

Dissecting Medullary Raphe Neurons Regulating Multiple Thermogenic Pathways

This paper identifies RPa-vGluT3 neurons as critical regulators of thermogenesis by coordinating sympathetic and somatic motor outputs to increase body temperature.

Role Of Pcdh15 In The Development Of Intrinsic Polarity Of Inner Ear Hair Cells

The paper investigates the role of Pcdh15-CD2 in establishing intrinsic polarity of inner ear hair cells, showing its necessity for kinocilial migration and polarity restoration.

Parallel Labeled-Line Organization of Sympathetic Outflow for Selective Organ Regulation in Mice

The paper identifies two molecularly distinct subtypes of sympathetic preganglionic neurons in mice that selectively regulate gastrointestinal and adrenal functions through non-overlapping innervation patterns.

Col4a2-eGFP mouse model reveals the molecular and functional dynamics of basement membrane remodelling in hair follicle morphogenesis

The study uses a fluorescent mouse model to show that basement membrane dynamics during hair follicle development are spatially graded and influence progenitor cell behavior and organ shape.

Plasticity of Neural Connections Underlying Oxytocin-mediated Parental Behaviors of Male Mice

The paper identifies oxytocin neurons as key regulators of paternal caregiving in male mice and shows enhanced excitatory connections from lateral hypothalamus neurons in fathers.

Airway tissue stem cells reutilize the embryonic proliferation regulator, Tgfβ-Id2 axis, for tissue regeneration

This study identifies the Tgfβ-Id2 axis as a regulator of proliferation transitions in airway basal cells during development and regeneration, showing its role in tissue repair and potential in preventing hyperplasia.

Selective translation of epigenetic modifiers drives the developmental clock of neural stem cells

This study identifies Fbl's role in driving the developmental clock of neural stem cells through translational control of H3K27me3 modifiers.

Loss of CNOT9 begets impairment in gastrulation leading to embryonic lethality

This study shows that loss of CNOT9 leads to embryonic lethality due to impaired gastrulation, with defects in Lefty2 mRNA decay and cytoplasmic interactions with miRNA-RISC.

Synchronized mesenchymal cell polarization and differentiation shape the formation of the murine trachea and esophagus

The paper investigates the mechanisms regulating trachea and esophagus development in mice, showing that radial cell polarization and cartilage development control tube elongation and diameter.