Zifei Pei

TAR syndrome causal gene RBM8A is critical for embryonic bone development and proper Hedgehog signaling

This study shows that RBM8A is essential for bone development and Hedgehog signaling, with its deficiency causing skeletal defects and impaired endochondral ossification.

Co-opting regulation bypass repair (CRBR) as a gene correction strategy for monogenic diseases

The paper introduces CRBR, a gene correction strategy that repairs mutations in both mitotic and post-mitotic cells, demonstrated in a mouse model of Wolcott-Rallison syndrome.

Transcription factor-based gene therapy to treat glioblastoma through direct neuronal conversion

This paper demonstrates that overexpressing neural transcription factors can convert glioblastoma cells into neurons, inhibiting their proliferation and offering a potential therapeutic strategy.

Regeneration of dorsal spinal cord neurons after injury via in situ NeuroD1-mediated astrocyte-to-neuron conversion

This study demonstrates efficient regeneration of dorsal spinal cord neurons from reactive astrocytes after injury using NeuroD1-mediated in vivo reprogramming via AAV.

Reversing Glial Scar Back To Neural Tissue Through NeuroD1-Mediated Astrocyte-To-Neuron Conversion

This study converts reactive astrocytes into neurons in mice, reducing glial scar and restoring neural tissue by rebalancing neuron-glia ratios.