Zhuofan Lei

This study shows that isoflurane anesthesia and surgery cause chronic sex-dependent neurological issues in mice, linked to changes in brain transcriptomes and circulating extracellular vesicles.

This study shows that Hv1 deficiency in mice leads to increased mortality and immune dysfunction after TBI, with significant effects on splenic antibacterial defense and immune homeostasis.

This study identifies cGAS-mediated IFN-I signaling as a driver of disease progression in drug-refractory epilepsy, showing that targeting cGAS reduces epileptic phenotypes and inflammation.

This study shows that brain injury accelerates age-related microglial changes linked to hyperphagocytosis and neurodegeneration in old mice.

This study demonstrates efficient regeneration of dorsal spinal cord neurons from reactive astrocytes after injury using NeuroD1-mediated in vivo reprogramming via AAV.

This study converts reactive astrocytes into neurons in mice, reducing glial scar and restoring neural tissue by rebalancing neuron-glia ratios.