Menin-Inhibition Sensitizes Acute Myeloid Leukemia to CLEC12A-Directed CAR Cell Therapy
Johanna Rausch, Philipp Wendel, Margarita M. Dzama, Marlene Steiner, Fenja Gierschek, Viktor Fetsch, Lea Rebecca Knapp, Najla Abassi, Marie Kuhmann, Lilian Viehböck, Simon Weisemann, Nadezda Dolgikh, Jan Habermann, Catharina Lahrmann, Matthias Klein, , Michael W.M. Kühn
This paper shows menin inhibitors increase CLEC12A expression in AML, making it more responsive to CLEC12A-targeted CAR T cells, improving treatment outcomes.
bioRxiv · Feb 17, 2026 · PreprintCancer Biology