Development of D-box peptides to inhibit the Anaphase Promoting Complex/Cyclosome
Rohan Eapen, Cynthia N. Okoye, Christopher J. Stubbs, Marianne Schimpl, Thomas Tischer, Eileen J. Fisher, Maria Zacharopoulou, Fernando Jose Ferrer, David Barford, David R. Spring, Catherine Lindon, Christopher Phillips, Laura S. Itzhaki
This study develops D-box peptides that inhibit APC/C by binding Cdc20, showing they are more potent than Apcin and can drive protein degradation.
eLife · Sep 1, 2025Peer-reviewedBiochemistry