Microglial SWELL1 Deficiency Drives Male-Specific Seizure Vulnerability but Paradoxical Neuroprotection through Impaired Phagocytosis
Abhijeet S. Barath, Aastha Dheer, Laura Montier, Mekenzie M Peshoff, Emily C. Dale, Flavia Goche, Thanh Thanh L. Nguyen, Mastura Akter, Fangfang Qi, Dimitrios Kleidonas, Lauren Harris, Sarah A. Jewanee, Anthony D. Umpierre, Dale B. Bosco, Koichiro Haruwaka, , Long‐Jun Wu
This study shows that microglial SWELL1 deficiency increases male-specific seizure severity but protects neurons through impaired phagocytosis and reduced neuroactive metabolite release.
JCI Insight · Jun 21, 2026Peer-reviewedNeuroscience