Author

Francesca Ornaghi

The San Raffaele Telethon Institute for Gene Therapy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3

Frequent Co-Authors

Lawrence G. WrabetziD· 2 shared M. Laura FeltriiD· 2 shared Pietro FrattaiD· 2 shared Sophie BeliniD· 2 shared Akihiro Ishii· 1 shared Alessandra BolinoiD· 1 shared Angela GrittiiD· 1 shared Angelo QuattriniiD· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersNeuroscience

Lawrence G. WrabetzORCID

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3 papers

Recent·Most cited

Therapeutic advantages of combined gene/cell therapy strategies in a murine model of GM2 gangliosidosis

Davide Sala, Francesca Ornaghi, Francesco Morena, Chiara Argentati, Manuela Valsecchi, Valeria Alberizzi, Roberta Di Guardo, Alessandra Bolino, Massimo Aureli, Sabata Martino, Angela Gritti

This study shows that combining gene therapy and bone marrow transplantation in a mouse model of GM2 gangliosidosis improves lifespan and reduces disease symptoms more effectively than either treatment alone.

Molecular Therapy — Methods & Clinical Development · Mar 16, 2022Peer-reviewedGenetics

A nonsense mutation in Myelin Protein Zero causes congenital hypomyelination neuropathy through altered P0 membrane targeting and gain of abnormal function

Pietro Fratta, Francesca Ornaghi, Gabriele Dati, Desirée Zambroni, Paola Saveri, Sophie Belin, Patrizia D’Adamo, Michael E. Shy, Angelo Quattrini, M. Laura Feltri, Lawrence G. Wrabetz

Human Molecular Genetics · Sep 18, 2018Peer-reviewedNeuroscience

Neuregulin 1 type III reduces severity in a mouse model of Congenital Hypomyelinating Neuropathy

Sophie Belin, Francesca Ornaghi, Ghjuvan’Ghjacumu Shackleford, Jie Wang, Cristina Scapin, Camila Lopez‐Anido, Nicholas J. Silvestri, Neil Robertson, Courtney Williamson, Akihiro Ishii, Carla Taveggia, John P. Svaren, Rashmi Bansal, Markus H. Schwab, Klaus‐Armin Nave, , Lawrence G. Wrabetz

This study shows that increasing neuregulin 1 type III in neurons improves myelination in a mouse model of congenital hypomyelinating neuropathy without relying on Egr2 or typical myelin genes.

bioRxiv · Aug 7, 2018 · PreprintNeuroscience