John P. Svaren

This study identifies a NR2F-regulated gene network in Schwann cells, revealing enrichment for nonmyelinating Schwann cell genes and novel transcription factor interactions.

This study shows that activating XBP1s reduces disease severity in CMT1B models by mitigating ER stress and mutant protein toxicity in Schwann cells.

NetREm identifies cell-type-specific transcription factor coordination for gene regulation using single-cell data and validates findings with functional genomics.

The paper identifies cooperative transcription factors in oligodendrocytes using single-cell multi-omics data and validates their regulatory roles through experimental analysis.

This study investigates whether injury-induced enhancers in Schwann cells are pre-programmed or activated de novo, and identifies JUN's role in regulating these enhancers to drive repair gene expression.

The paper shows that restoring Schwann cell c-Jun rescues nerve regeneration failures in aging and chronic denervation by enhancing regenerative support.

This study shows that increasing neuregulin 1 type III in neurons improves myelination in a mouse model of congenital hypomyelinating neuropathy without relying on Egr2 or typical myelin genes.