Distinct evolutionary trajectories following loss of RNA interference in Cryptococcus neoformans
Jun T. Huang, Connor J. Larmore, Shelby J. Priest, Ziyan Zoe Xu, Fred S. Dietrich, Vikas Yadav, Paul M. Magwene, Sheng Sun, Joseph Heitman
The paper identifies RNAi loss-of-function mutations in Cryptococcus neoformans and shows they can lead to hypermutation when combined with transposon burdens.
Proceedings of the National Academy of Sciences · Nov 13, 2024Peer-reviewedGenetics