ImmunologybioRxiv
Detection of succinate by intestinal tuft cells triggers a type 2 innate immune circuit
M. S. Nadjsombati, J. W. McGinty, M. R. Lyons-Cohen…·J. von Moltke
The paper identifies succinate as a ligand that activates intestinal tuft cells to initiate type 2 immune responses, linking microbial metabolism to immune sensing.
DOI 10.1016/j.immuni.2018.06.016