R. M. Locksley

Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase

This study characterizes the pH-specific enzymatic activity and ligand binding of mouse AMCase using structural and computational methods, revealing dual activity optima at pH 2 and 7.

Group 2 innate lymphoid cells constrain type 3/17 lymphocytes in shared stromal niches to restrict liver fibrosis

The paper investigates the role of IL-5+ lymphocytes and type 3/17 lymphocytes in liver fibrosis, showing their spatial relationship and cross-regulation in fibroblast niches.

IL-13-programmed airway tuft cells produce PGE2, which promotes CFTR-dependent mucociliary function

The paper identifies IL-13-programmed airway tuft cells that produce PGE2, which enhances CFTR-dependent mucociliary function in allergic airways.

Inhibition of the tuft cell/ILC2 axis reduces gastric tumor development in mice

The paper shows that inhibiting the tuft cell/ILC2 axis reduces gastric tumor growth in mice by disrupting a circuit that promotes tumor formation.

Alveolar macrophages strictly rely on GM-CSF from alveolar epithelial type 2 cells before and after birth

This study identifies that alveolar epithelial type 2 cells provide essential GM-CSF for alveolar macrophage development and maintenance before and after birth.

Type 2 innate immunity regulates hair follicle homeostasis to control Demodex pathosymbionts

This study shows that type 2 innate immunity, via ILC2s, regulates hair follicle homeostasis and maintains commensal Demodex mite colonization.

Differences in the chitinolytic activity of mammalian chitinases on soluble and crystalline substrates

This study identifies mutations that enhance chitinase activity on oligomeric substrates but not crystalline chitin, highlighting the importance of using physiologically relevant substrates in enzyme engineering.

Skin inflammation driven by differentiation of quiescent tissue-resident ILCs into a spectrum of pathogenic effectors

The paper shows that psoriasis is driven by the reprogramming of quiescent skin-resident ILCs into pathogenic effectors through epigenetic and transcriptional changes.

Detection of succinate by intestinal tuft cells triggers a type 2 innate immune circuit

The paper identifies succinate as a ligand that activates intestinal tuft cells to initiate type 2 immune responses, linking microbial metabolism to immune sensing.