Author

J. von Moltke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

J. W. McGinty· 2 shared L. M. Webeck· 2 shared M. S. Nadjsombati· 2 shared A. Barilli· 1 shared A. Bendesky· 1 shared A. Gregorieff· 1 shared A. Rochette· 1 shared C. Fung· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersImmunology

J. W. McGinty

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4 papers

Recent·Most cited

Tuft cell-derived acetylcholine regulates epithelial fluid secretion

T. E. Billipp, C. Fung, L. M. Webeck, D. B. Sargent, M. B. Gologorsky, M. M. McDaniel, D. N. Kasal, J. W. McGinty, K. A. Barrow, L. M. Rich, A. Barilli, M. Sabat, J. S. Debley, R. Myers, M. R. Howitt, J. von Moltke

This study shows that tuft cell-derived acetylcholine in the intestine triggers immediate fluid secretion, distinct from its role in immune responses, and is involved in Type 2 inflammation and helminth clearance.

bioRxiv · Mar 17, 2023 · PreprintImmunology

Genetic mapping reveals Pou2af2-dependent tuning of tuft cell differentiation and intestinal type 2 immunity

M. S. Nadjsombati, N. Niepoth, L. M. Webeck, E. A. Kennedy, D. L. Jones, M. T. Baldridge, A. Bendesky, J. von Moltke

The paper identifies Pou2af2 isoform usage as a regulator of tuft cell differentiation and intestinal type 2 immunity through genetic mapping in mice.

bioRxiv · Oct 19, 2022 · PreprintImmunology

Direct reprogramming of the intestinal epithelium by parasitic helminths subverts type 2 immunity

D. Karo-Atar, S. Ouladan, T. Javkar, L. Joumier, M. K. Matheson, S. Merritt, S. Westfall, A. Rochette, M. E. Gentile, G. Fontes, G. J. Fonseca, M. Parisien, L. Diatchenko, J. von Moltke, M. Malleshaiah, , I. L. King

This study shows that helminth infection reprograms intestinal epithelium into a fetal-like state, generating stem cells that inhibit type 2 immunity and promote helminth survival.

bioRxiv · Sep 25, 2021Immunology

Detection of succinate by intestinal tuft cells triggers a type 2 innate immune circuit

M. S. Nadjsombati, J. W. McGinty, M. R. Lyons-Cohen, J. L. Pollack, G. A. Nagana Gowda, D. J. Erle, R. M. Locksley, D. Raftery, J. von Moltke

The paper identifies succinate as a ligand that activates intestinal tuft cells to initiate type 2 immune responses, linking microbial metabolism to immune sensing.

bioRxiv · Apr 29, 2018Immunology