Author

J. W. McGinty

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. von Moltke· 2 shared A. Barilli· 1 shared C. Fung· 1 shared D. B. Sargent· 1 shared D. J. Erle· 1 shared D. N. Kasal· 1 shared D. Raftery· 1 shared G. A. Nagana Gowda· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

J. von Moltke

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2 papers

Recent·Most cited

Tuft cell-derived acetylcholine regulates epithelial fluid secretion

T. E. Billipp, C. Fung, L. M. Webeck, D. B. Sargent, M. B. Gologorsky, M. M. McDaniel, D. N. Kasal, J. W. McGinty, K. A. Barrow, L. M. Rich, A. Barilli, M. Sabat, J. S. Debley, R. Myers, M. R. Howitt, J. von Moltke

This study shows that tuft cell-derived acetylcholine in the intestine triggers immediate fluid secretion, distinct from its role in immune responses, and is involved in Type 2 inflammation and helminth clearance.

bioRxiv · Mar 17, 2023 · PreprintImmunology

Detection of succinate by intestinal tuft cells triggers a type 2 innate immune circuit

M. S. Nadjsombati, J. W. McGinty, M. R. Lyons-Cohen, J. L. Pollack, G. A. Nagana Gowda, D. J. Erle, R. M. Locksley, D. Raftery, J. von Moltke

The paper identifies succinate as a ligand that activates intestinal tuft cells to initiate type 2 immune responses, linking microbial metabolism to immune sensing.

bioRxiv · Apr 29, 2018Immunology