Author

H. Nagase

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Assay:proteomics· 1

Frequent Co-Authors

S. D. Scilabra· 2 shared A. Inoue· 1 shared A. M. E. Gremida· 1 shared A. P. Carreca· 1 shared C. Scavenius· 1 shared C. Suno-Ikeda· 1 shared E. Asai· 1 shared E. H. Mogensen· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

S. D. Scilabra

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structural and Dynamic Insights into the Biased Signaling Mechanism of the Human Kappa Opioid Receptor

C. Suno-Ikeda, R. Nishikawa, R. Suzuki, S. Iwata, T. Takai, T. Ogura, M. Hirose, A. Inoue, E. Asai, R. Kise, Y. Sugita, T. Kato, H. Nagase, T. Saito, K. Katayama, , R. Suno

This study investigates the structural dynamics of the human KOR-Gi signaling complex with G-protein-biased and balanced agonists, identifying key residues involved in signaling bias.

bioRxiv · Apr 11, 2024 · PreprintBiophysics

Uncovering the ligandome of low-density lipoprotein receptor-related protein 1 in cartilage: a top-down approach to identify therapeutic targets

K. Yamamoto, C. Scavenius, M. M. Meschis, E. H. Mogensen, A. M. E. Gremida, I. B. Thogersen, S. Bonelli, S. D. Scilabra, S. Santamaria, J. Ahnström, G. Bou-Gharios, J. J. Enghild, H. Nagase

This study identifies the ligandome of LRP1 in cartilage using a top-down approach, revealing novel ligands and their role in osteoarthritis.

bioRxiv · Mar 2, 2022 · PreprintCell Biology

TIMP-3 facilitates binding of target metalloproteinases to the endocytic receptor LRP-1 and promotes scavenging of MMP-1

A. P. Carreca, V. M. Pravata, G. Murphy, H. Nagase, L. Troeberg, S. D. Scilabra

This study identifies MMP-1 as a new LRP-1 ligand and shows TIMP-3 enhances its binding to LRP-1, promoting scavenging of MMP-1.

bioRxiv · Dec 23, 2019Biochemistry